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Pathology notes (continued)

New York: Brunner/Mazzel Inc..

In modern instrumentation in polarography and voltammetry, a personal computer (PC) is often connected to a potentiostat, by inserting an analog-to-digital converter (ADC) and a digital-to-analog converter (DAC) between them (Fig. 5.46) [28]. The DAC converts digital signals from the PC to analog signals and transfers them to the potentiostat. The ADC, on the other hand, converts analog signals from the potentiostat to digital signals and transfers them to the PC. This digital instrumentation offers various advantages. (i) It is suitable for staircase, square-wave or pulse polarography and voltammetry. Using a simple computer program, the PC generates a staircase, squarewave or pulse voltage to be applied to the cell and then it reads the current flowing through the cell circuit as digital signals and processes them in a variety of ways. In SW and pulse polarography and voltammetry, the program samples only the current that is solely faradaic (see Fig. 5.15). (ii) The digital instrumentation is useful in rapid-scan cyclic voltammetry. Data from the cyclic voltammogram are first stored in a memory device and then processed or graphically presented. With a sophisticated digital instrument and a ultramicroelectrode, potential sweeps of 1 000 000 V s 1 or more are possible. (iii) The digital simulation makes mechanistic studies of electrode processes by cyclic voltammetry much easier. Cyclic voltammograms readily provide qualitative information about electrode processes, but, without the simulation technique, it is rather difficult to get quantitative mechanistic information from them.

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(1995) Improved cationic lipid formulations for in vivo gene therapy Ann NY Acad Sci 772: 126 139 Fogler, WE, Swartz, GM, Jr, Alving, CR (1987) Antibodies to phospholipids and liposomes: binding of antibodies to cells Biochim Biophys Acta 903(2): 265 272 Freed, LE, Hollander, AP, Martin, I, Barry, JR, Langer, R, Vunjak-Novakovic, G (1998) Chondrogenesis in a cell-polymer-bioreactor system Exp Cell Res 240(1): 58 65 Gao, X, and Huang, L (1991) A novel cationic liposome reagent for ef cient transfection of mammalian cells Biochem Biophys Res Commun 179(1): 280 285 Hatton, JD, and Lin, L (1992) Demonstration of speci c neuronal cell groups in rat brain by beta-galactosidase enzyme histochemistry J Neurosci Methods 45(3): 147 153 Ikeda, T, Kubo, T, Nakanishi, T, Arai, Y, Kobayashi, K, Mazda, O.

The second year medical students have written a petition and all 121 of them have signed it. The petition asks the Dean of the Medical School and the Vice-Chancellor of the University to act immediately to reform the medical school curriculum. Here is part of it: We the undersigned petition that medical students are given the same standard of education with the same level of intellectual challenge as all other students of this University. Though facts and skills are essential to us as future doctors we entreat that: 1 The rst year programme be altered so that students do not repeat material already studied in school. 2 Pre-clinical teaching staff co-ordinate to ensure that material is not repeated. 3 A distinction is made between essential, recommended and optional learning (we presently have to spend days cramming factual material we will never use, which will soon date, or which can be easily looked up if we need it). 4 The ethics, sociology, psychology, humanities and communication components be increased as the pre-clinical load is reduced. 5 Time for student-directed learning be increased substantially. Dr Crossley, a young ethics lecturer, has repeatedly encouraged and supported the students in these views, and is delighted that they have written the petition. However, when the second year rep asks him to sign it, he is not sure he should. Crossley is approaching the end of a 3year xed term contract, has made both friends and enemies at the Medical School, and is learning that job security comes at a price. If he signs it the Dean will notice and the Dean is shortly also to rule on whether Crossley s contract should be extended or the job advertised anew.

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